GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs4765219 | 1 | rs11833002 | chr12:124446616 | DNAH10 | chr12:124247042-124420265:+ | 0.26 | 6.91 | 8.5E-12 | Waist-to-hip ratio adjusted for body mass index |
| BRCA | cis | rs4765219 | 1 | rs11835839 | chr12:124431049 | DNAH10 | chr12:124247042-124420265:+ | 0.26 | 6.78 | 1.92E-11 | Waist-to-hip ratio adjusted for body mass index |
| BRCA | cis | rs12435908 | 1 | rs11844747 | chr14:65870128 | LOC645431 | chr14:65877313-65879335:- | 0.31 | 6.53 | 1.04E-10 | Ischemic stroke |
| BRCA | cis | rs2337406 | 1 | rs11845269 | chr14:107139868 | LOC100133469 | chr14:106938455-106951529:+ | 0.15 | 3.59 | 0.000349 | Alzheimer's disease (late onset) |
| BRCA | cis | rs17796783 | 1 | rs11851274 | chr14:85791952 | FLRT2 | chr14:85996488-86094269:+ | -0.08 | -3.39 | 0.000717 | Heart rate |
| BRCA | cis | rs11858210 | 1 | rs11858210 | chr15:79078358 | CTSH | chr15:79214092-79237420:- | 0.17 | 4.91 | 1.08E-6 | Post bronchodilator FEV1/FVC ratio |
| BRCA | cis | rs78153629 | 1 | rs11858714 | chr15:40717447 | C15orf23 | chr15:40674922-40686488:+ | 0.4 | 10.68 | 2.37E-25 | Heschl's gyrus morphology |
| BRCA | cis | rs78153629 | 1 | rs11858714 | chr15:40717447 | C15orf57 | chr15:40823540-40857252:- | 0.19 | 3.93 | 9.19E-5 | Heschl's gyrus morphology |
| BRCA | cis | rs8050907 | 1 | rs11862083 | chr16:4649720 | NMRAL1 | chr16:4511696-4526307:- | -0.28 | -5.45 | 6.25E-8 | Obesity-related traits |
| BRCA | cis | rs4889609 | 1 | rs11862744 | chr16:31057800 | HSD3B7 | chr16:30996519-31000473:+ | 0.23 | 7.19 | 1.23E-12 | Response to metformin (IC50) |
| BRCA | cis | rs4889609 | 1 | rs11862744 | chr16:31057800 | MYST1 | chr16:31128985-31142713:+ | 0.2 | 7.38 | 3.17E-13 | Response to metformin (IC50) |
| BRCA | cis | rs4889609 | 1 | rs11862744 | chr16:31057800 | ORAI3 | chr16:30960405-30966258:+ | 0.1 | 3.54 | 0.000419 | Response to metformin (IC50) |
| BRCA | cis | rs4889609 | 1 | rs11862744 | chr16:31057800 | SETD1A | chr16:30968615-30995981:+ | 0.11 | 3.46 | 0.000567 | Response to metformin (IC50) |
| BRCA | cis | rs4889609 | 1 | rs11862744 | chr16:31057800 | ZNF689 | chr16:30614701-30621682:- | 0.11 | 3.52 | 0.000442 | Response to metformin (IC50) |
| BRCA | cis | rs11248850 | 1 | rs11865131 | chr16:163667 | NPRL3 | chr16:134273-188672:- | 0.13 | 3.82 | 0.000139 | Red blood cell traits |